College football picks, schedule: Predictions against the spread, odds for the first 25 games in Week 10

The first College Football Playoff rankings just released set the schedule for the rest of the 2022 season. Week 10 begins in earnest with two top-10 matchups involving SEC opponents that have direct implications for the league championship game and the playoff picture.

No. 1 Tennessee visits No. 3 Georgia in the SEC in the CBS game of the week. No. in AP Top 25 1 (Bulldogs) and no. 2 (Volunteers) It’s the 25th all-time regular-season matchup between the teams and comes a few weeks after Tennessee posted its biggest win in decades after handing Alabama. First loss of the season at Neyland Stadium. Now, the Vols will try to prove their mettle against the reigning national champion Dawgs, who will present the nation’s top-ranked offense with their toughest defensive test all season.

As if that was not enough, no. 6 Alabama Tigers favorite atmosphere in No. 10 LSU visits: Death Valley night game. While the Bayou Bengals look for a signature win in Year 1 under Chip Kelly, the Crimson Tide can’t afford a second loss if they still believe in a playoff chance. A win for Bama would be a significant rebound from the Tennessee loss and a key feather in its bid to lock up the SEC West and meet either Georgia or Tennessee in the SEC Championship Game.

The SEC isn’t the only Saturday conference that gets attention. While Big Ten powers No. 2 Ohio State (at Northwestern) and No. 5 Michigan (at Rutgers) are massive favorites on the road, the ACC’s top team is also on the road, but in a very tough matchup with No. 1. 3 Clemson visits Notre Dame as a 3.5-point favorite. No. 13 Kansas State no. 7 might have two more losses than TCU (vs. Texas Tech), however, as the Wildcats hope to play in the Big 12 Championship Game, Texas’ No. 24 faces a crucial game against

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By the time Saturday’s action wraps up, we’ll have a clearer picture of what the second set of CFP rankings will look like after Tuesday. Be sure to stay tuned to CBS Sports throughout the day for college football coverage from the opening kickoff. Let’s take a look at our expert picks for the best games in Week 10.

Odds by Caesars Sportsbook | East at all times

No. No. 1 Tennessee at 3 Georgia

Special game | Georgia Bulldogs vs. Tennessee Volunteers

3:30 pm | CBS, CBSSports.com, CBS Sports AppI’ll go out on a limb and take Tennessee to win outright. Don’t get me wrong, I’ll score those points too, but this Tennessee offense can’t be stopped even by a defense as talented and deep as Georgia’s. The Volunteers will operate at warp speed and expose the absence of linebacker Nolan Smith while using quarterback Hendon Hooker and run Jabari Small and Jaylen Wright up the floor to set up chunk plays up top. Stetson Bennett couldn’t keep up, and Tennessee would have its biggest win in decades. Prediction: Tennessee +8.5 — Barrett Sally

No. 6 Alabama no. 10 at LSU

Special game | LSU Tigers vs. Alabama Crimson Tide

7 pm | ESPN, fuboTV (try it for free) — According to the College Football Playoff rankings, LSU is a top-10 team, but I don’t think LSU is one of the top 10 teams in the country. Alabama has flaws and isn’t the same juggernaut dynamo we’re used to seeing, but this is the best overall team in this tournament. Now, is Bama going to win by two touchdowns over LSU? I’m not so sure. The home environment in Baton Rouge, Louisiana will be tough for Bryce Young and the Alabama offense, and I think the Crimson Tide will have trouble dragging out the fight. I take the points. Prediction: LSU +13 — Tom Fornelli

No. 24 Texas no. 13 at Kansas State

7 pm | FS1, fuboTV (try it for free) — Texas has owned K-State for the past half-decade, but this is the best version of the Wildcats so far. Texas’ Quinn Evers struggled in his first road start, and Kansas State won’t be a friendly border for the young quarterback. The ‘Cats hung onto the ball and controlled possession to come away with a convincing win. Prediction: Kansas State +2.5 — Shehan Jayaraja

No. at Notre Dame. 4 Clemson

Special game | Notre Dame Irish vs. Clemson Tigers battle

7:30 pm | NBC, fuboTV (try it for free) — The playbook for Notre Dame against Ohio State was to lean on defense and play a ball-control game that allowed the Fighting Irish to hang with the Buckeyes as deep into the game as possible. Clemson under Dabo Swinney has a history of leaning on its defense, playing down the field and trying to limit mistakes in this big regular-season matchup. A defensive battle leads to a lot of field goal attempts and fewer points on the scoreboard. Prediction: Under 44 years of age — Chip Patterson

Which college football picks can you confidently make in Week 10, and which top-25 teams will land hard? Visit SportsLine to see which teams will win and cover the spread — from a proven computer model that has made nearly $3,000 in profits over the past six-plus seasons — and find out.

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